The Danger of Dengue #MsiaEndsDengue – Dr Khoo Yoong Khean

Source: www.topnews.in

Source: www.topnews.in

Introduction and Epidemiology

Practicing in a tropical country, it is impossible not to come across cases of dengue fever. Over the years, we have had countless health campaigns regarding dengue from television advertisements to public roadshows. But dengue fever still seems to be a problem for developing countries like Malaysia. This proves that dengue fever is a big problem not only locally, but internationally as well.

World Health Organization (WHO) estimates over 40% of the global population are at risk from dengue and 50 to 100 million cases are reported yearly.  The disease is seen spreading from tropical countries to countries like Portugal, France and Croatia.

In Malaysia, dengue fever cases are on the rise from 6,000 cases in 1995 to over 40,000 in 2010,  and this number is rising.

What is dengue fever?

Dengue fever is a vector borne disease, carried by two types of mosquitoes, Aedes aegypti and Aedes albopictus. It is caused by a virus with 4 distinct serotypes, DENV-1 to 4. Each serotype confers lifelong immunity to its infection but sequential infections with other serotypes might cause even more dangerous complications of dengue.

It has an incubation period (time between exposure to the disease and the appearance of symptoms) of 4 to 7 days after getting bitten by the mosquito and usually last 3 to 10 days, barring any complications. The course of the disease is typically divided into 3 phases; the febrile (fever) phase, the critical phase and the recovery phase.

Source: blog.docsuggest.com -

Source: blog.docsuggest.com –

Febrile phase

Fever is the first symptom to appear. This phase typically last 2 to 7 days and patients will experience body and joint aches, headaches (typically characterized by retro-orbital pain/pain behind the eyes), giddiness, nausea (feeling an urge to vomit), vomiting and generalized lethargy (feeling of weariness, tiredness, or lack of energy).

Blood investigations early in the febrile phase might be normal or merely show features of viral illness. Therefore, after taking a careful history, with a high degree of suspicion of dengue, the doctor will usually ask for a repeat of the blood tests to confirm the diagnosis of dengue fever.

There might also be mild bleeding over the mucosa such as gum bleeding and heavier menses in women.

Critical phase

This is the dangerous phase of the infection.  It usually starts from the 3rd to 5th day of the illness. In some cases, it might even start as late as the 7th day of illness. This phase lasts about 24 to 48 hours.

In this phase, there is increased capillary permeability, where fluid in the body seeps out from the blood vessels, causing bleeding, accumulation of fluid in organs, like in the lungs, and dehydration.

There are several warning signs that the doctor will look out for to assess the severity of the illness, which are:

  1. Persistent vomiting
  2. Lethargy (feeling of weariness, tiredness, or lack of energy)
  3. Mucosal bleeding (example: gum bleeding, nose bleeding, heavy menses bleeding)
  4. Persistent abdominal pain
  5. Tender or painful abdomen on examination
  6. Evidence of fluid accumulation in lungs
  7. Changes in blood tests

If the illness is not well treated at this point, the patient could go into shock and die.

Recovery phase

As the name suggest, this is when the body starts to recover. Fluid leaked out from blood vessels is reabsorbed, earlier symptoms gradually disappear and the general wellbeing of the patient improves. The typical dengue rash may appear in the recovery phase.

How to treat?

In the febrile phase, most patients can be treated as outpatients and need not be admitted to the hospital unless there are other complications.

Source: ryannreyes.tumblr.com

Source: ryannreyes.tumblr.com

Dengue fever is a viral illness and the main treatment is symptomatic. The doctor will assess the patients’ status and if deemed safe to be discharged, most of the time, the treatment is to control the fever using anti-pyretics such as Paracetamol. Patients are encouraged to drink plenty of fluids at this time.

In subsequent visits to the clinic or hospital, repeated blood tests are done to assess and confirm the diagnosis of dengue. Depending on the hydration status and blood tests, the doctor might admit dengue patients for observation.

At this time, fluids will be given intravenously to help keep the body hydrated. In severe cases, blood transfusion might be needed. Once the critical phase is over, intravenous fluid will be weaned off and patient will be discharged once he/she is able to take orally well.

Complications of dengue fever

Severe dehydration and fluid leakage is the greatest enemy. This will cause circulatory collapse (failure of the body to maintain adequate blood supply to vital organs and continue normal bodily functions) in the patient and is potentially fatal. The dengue virus is also known to cause hepatitis (swelling and inflammation of the liver). The doctor will monitor your liver function via blood tests. In severe cases of bleeding, blood transfusion will be needed.

Source: niswarthsewa.org

Source: niswarthsewa.org

How to prevent dengue?

Prevention is better than cure and in dengue fever, this is no exception. It is important to make sure there is no stagnant water surrounding the house to prevent the breeding of the mosquitoes. Some neighbourhoods will have regular mosquito fogging. If you are traveling to remote areas, like jungle trekking, insect repellants can be useful.

Dengue fever is a notifiable disease under the Ministry of Health and confirmed cases will be visited and investigated by health officers. Fogging will also be done at the area of infection.

Conclusion

Both the community and healthcare personnel should be vigilant on detecting and managing dengue cases. Early detection of dengue fever has been proven to save lives.

WHO has very active dengue fever initiatives like the Global Alert and Response Program, which is an integrated global alert and response system for epidemics and other public health emergencies.  For more information, please visit http://www.who.int/csr/en/index.html.

At the moment, dengue vaccine is not available yet, but efforts are in place to achieve this in the near future. For more information on the efforts of dengue vaccination, please visit http://www.denguevaccines.org/.

Dr. Khoo Yoong Khean is the Managing Editor of the Malaysian Medical Gazette. He currently works in one of the busiest Emergency Department in Malaysia. Find out more about him at The Team page.

References

[This article belongs to The Malaysian Medical Gazette. Any republication (online or offline) without written permission from The Malaysian Medical Gazette is prohibited.] 

4 comments for “The Danger of Dengue #MsiaEndsDengue – Dr Khoo Yoong Khean

  1. November 12, 2013 at 5:50 am

    The clear and present danger is in relying on folk remedies and delaying admission until it is too late. One such common belief is that papaya leaves will “cure” dengue. We posted an article on this:
    http://alt.medicine.com.my/2013/07/does-taking-papaya-leaves-cure-dengue/

  2. Helen
    November 12, 2013 at 2:26 pm

    “Dengue fever is a notifiable disease …….. ”

    In March 2013, I had dengue fever, due to my medical history was admitted, then no “health officers” or DBKL came to my neighborhood to check or do fogging whatever, weeks later my immediate neighbor too was down with dengue fever & admitted. We suspect the abandoned vacant house was the breeding ground despite our trouble to highlight this matter, no one wants to take responsibility. So today, I see a big banner in the next garden “Ini adalah kawasan wabak dengi” thus the chain reaction !!

  3. Jonathan Goh
    November 18, 2013 at 10:03 am

    Great article on dengue Dr Khoo and I myself am facing a severe mosquito infestation around my neighborhood. So far everyone in the area have been making sure there are no presence of stagnant water and the weekly smogging does not seem to help. I suspect is the huge gardens behind each house the neighborhood are breeding grounds. Nothing we can do about them so I have tried DIY mosquito traps and am in the midst of getting lavender seeds. Hope this helps anyone who are at their wits end so give this trap a try.I am not a happy camper when I am bathing my pets.

    instructions on my DIY trap i found on google.

    Items needed:
    1 cup of water
    1/4 cup of brown sugar
    1 gram of yeast
    1 2-liter bottle

    HOW:
    1. Cut the plastic bottle in half.
    2. Mix brown sugar with hot water. Let cool. When cold, pour in the bottom half of the bottle.
    3. Add the yeast. No need to mix. It creates carbon dioxide, which attracts mosquitoes.
    4. Place the funnel part, upside down, into the other half of the bottle, taping them together if desired.
    5. Wrap the bottle with something black, leaving the top uncovered, and place it outside in an area away from your normal gathering area. (Mosquitoes are also drawn to the color black.)

    Change the solution every 2 weeks for continuous control.

    Refference- http://www.thesurvivalistblog.net/homemade-mosquito-trap/

  4. Dr Sofwan Albar
    January 31, 2014 at 5:51 pm

    Hi guys. Nice article about dengue. Unfortunately my job is to deal with dengue outbreak in Selangor and to finalize report on dengue mortality. It was a cruel process as you started to filter the chronology in details and the outcome of the disease. It is all about breaking the safety net. The process goes as early as individual then to community level then ED, hospital admission, ending up at ICU or somewhere else. Is there any safe place or dengue free in Selangor? I really doubt that. Our theme parks are full with breeding area, left over construction work such bucket, safety helmet that are waiting to be filled with rain water for the next hours or days. Dont go to this areas at dawn, supermarket, kedai runcit, shopping malls etc. Aedes mosquito is attracted to carbon dioxide. If you are thinking to have a nice stroll or jog in the park, it is best to wear mosquito repellants, where long sleeves clothing. These Aedes love to bite at dawn and attracted to excessive carbon dioxide exhalation. Further, Aedes mosquito is a lazy mosquito. They will not travel that far to bite people. Always be alarmed if your area is involve with fogging activities.

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